1H detection and dynamic nuclear polarization-enhanced NMR of A{beta}1-42 fibrils [Biophysics and Computational Biology]
 

1H detection and dynamic nuclear polarization-enhanced NMR of A{beta}1-42 fibrils [Biophysics and Computational Biology]

Salima Bahri, Robert Silvers, Brian Michael, Kristaps Jaudzems, Daniela Lalli, Gilles Casano, Olivier Ouari, Anne Lesage, Guido Pintacuda, Sara Linse, Robert G. Griffin...
Date: 2021-12-30

Several publications describing high-resolution structures of amyloid-? (A?) and other fibrils have demonstrated that magic-angle spinning (MAS) NMR spectroscopy is an ideal tool for studying amyloids at atomic resolution. Nonetheless, MAS NMR suffers from low sensitivity, requiring relatively large amounts of samples and extensive signal acquisition periods, which in turn... Read More


PNAS:
Number: 1
Volume: 119