1D and 2D NMR for KRAS:Ligand Binding
 

1D and 2D NMR for KRAS:Ligand Binding

Fragment-based screening by ligand-observed 1D NMR and binding interface mapping by protein-observed 2D NMR are popular methods used in drug discovery. These methods allow researchers to detect compound binding over a wide range of affinities and offer a simultaneous assessment of solubility, purity, and chemical formula accuracy of the target compounds and the ^(15)N-labeled protein when examined by 1D and 2D NMR, respectively. These methods can be applied for screening fragment binding to the...

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