[NMR paper] NMR spectroscopy to study the fate of metallodrugs in cells
NMR spectroscopy to study the fate of metallodrugs in cells
Metal-based drugs can modulate various biological processes and exhibit a rich variety of properties that foster their use in biomedicine and chemical biology. On the way to intracellular targets, ligand exchange and redox reactions can take place, thus making metallodrug speciation in vivo a challenging task. Advances in NMR spectroscopy have made it possible to move from solution to live-cell studies and elucidate the transport of metallodrugs and interactions with macromolecular targets in a...
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04-23-2021 07:01 AM
[NMR paper] Insight into the antitumor actions of sterically hindered platinum(ii) complexes by a combination of STD NMR and LCMS techniques.
Insight into the antitumor actions of sterically hindered platinum(ii) complexes by a combination of STD NMR and LCMS techniques.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.rsc-cdn.org-oxygen-assets-logo-rsc-logo-btn-small.gif Related Articles Insight into the antitumor actions of sterically hindered platinum(ii) complexes by a combination of STD NMR and LCMS techniques.
Metallomics. 2020 03 25;12(3):427-434
Authors: Wang Z, Fang L, Zhao J, Gou S
Abstract
Sterically hindered platinum(ii)...
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01-29-2021 05:13 PM
[NMR paper] Structure of the Functionally Important Extracellular Loop C of Human Aquaporin 1 Obtained by Solid-State NMR under Nearly Physiological Conditions.
Structure of the Functionally Important Extracellular Loop C of Human Aquaporin 1 Obtained by Solid-State NMR under Nearly Physiological Conditions.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Structure of the Functionally Important Extracellular Loop C of Human Aquaporin 1 Obtained by Solid-State NMR under Nearly Physiological Conditions.
J Phys Chem B. 2019 09 12;123(36):7700-7710
Authors: Dingwell DA, Brown LS, Ladizhansky V
Abstract
Human...
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08-13-2020 10:14 PM
[NMR paper] Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
Metab Brain Dis. 2018 10;33(5):1661-1668
Authors: Zhou Q, Zheng H, Chen J, Li C, Du Y, Xia H, Gao H
Abstract
Alzheimer's disease (AD) has been...
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05-09-2019 05:55 AM
DNP-Enhanced Ultrawideline Solid-State NMR Spectroscopy: Studies of Platinum in Metal-Organic Frameworks #DNPNMR
From The DNP-NMR Blog:
DNP-Enhanced Ultrawideline Solid-State NMR Spectroscopy: Studies of Platinum in Metal-Organic Frameworks #DNPNMR
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Kobayashi, T., et al., DNP-Enhanced Ultrawideline Solid-State NMR Spectroscopy: Studies of Platinum in Metal-Organic Frameworks. J Phys Chem Lett, 2016. 7(13): p. 2322-7.
https://www.ncbi.nlm.nih.gov/pubmed/27266444
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01-12-2017 03:48 AM
Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions
Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions
Abstract
Direct detection of the TROSY component of proton-attached 15N nuclei (15N-detected TROSY) yields high quality spectra with high field magnets, by taking advantage of the slow 15N transverse relaxation. The slow transverse relaxation and narrow line width of the 15N-detected TROSY resonances are expected to compensate for the inherently low 15N sensitivity. However, the sensitivity of...
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01-23-2016 03:35 PM
[NMR paper] NMR Spectroscopic Studies of Intrinsically Disordered Proteins at Near-Physiological Conditions.
NMR Spectroscopic Studies of Intrinsically Disordered Proteins at Near-Physiological Conditions.
Related Articles NMR Spectroscopic Studies of Intrinsically Disordered Proteins at Near-Physiological Conditions.
Angew Chem Int Ed Engl. 2013 Sep 20;
Authors: Gil S, Hošek T, Solyom Z, Kümmerle R, Brutscher B, Pierattelli R, Felli IC
Abstract
When approaching physiological conditions, solvent exchange of amide protons in intrinsically disordered proteins (IDPs) is so pronounced that it becomes a key feature to be considered in NMR experiment...
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10-12-2013 05:24 PM
[NMR paper] Fate of Pup inside the Mycobacterium Proteasome Studied by in-Cell NMR.
Fate of Pup inside the Mycobacterium Proteasome Studied by in-Cell NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png Related Articles Fate of Pup inside the Mycobacterium Proteasome Studied by in-Cell NMR.
PLoS One. 2013;8(9):e74576
Authors: Maldonado AY, Burz DS, Reverdatto S, Shekhtman A
Abstract
The Mycobacterium tuberculosis proteasome is required for maximum virulence and to resist killing by the host immune system. The prokaryotic ubiquitin-like protein, Pup-GGE,...
19F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions
Linear Mode
