NMR paper (1) H and (13) C NMR spectral assignments of chalcones bearing pyrazoline-carbothioamide groups.

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[NMR paper] (1) H and (13) C NMR spectral assignments of chalcones bearing pyrazoline-carbothioamide groups.

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06-21-2013, 01:10 PM

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(1) H and (13) C NMR spectral assignments of chalcones bearing pyrazoline-carbothioamide groups.

(1) H and (13) C NMR spectral assignments of chalcones bearing pyrazoline-carbothioamide groups.

(1) H and (13) C NMR spectral assignments of chalcones bearing pyrazoline-carbothioamide groups.

Magn Reson Chem. 2013 Jun 19;

Authors: Yoon H, Ahn S, Park M, Kim DW, Kim SH, Koh D, Lim Y

Abstract
Chalcones are known to act on various physiological targets. As a result, structural modifications of chalcones have been studied extensively. Benzochalcones, in which the A-ring of chalcone is substituted with a naphthalene unit, inhibits breast cancer resistance protein. Chalcones in which the ?,?-unsaturated carbonyl group is switched with a pyrazoline moiety are potent cytotoxic agents against various cancer cell lines, and chalcones with a pyrazoline-1-carbothioamide group instead of an ?,?-unsaturated carbonyl group exhibit antimicrobial activities. The present report describes hybrid molecules designed from benzochalcone and pyrazoline-carbothioamide. Methoxylation of plant-derived polyphenols alters their hydrophobicity, resulting in changes in biological function and intracellular compartmentation. In the current study, 22 novel methoxylated 3-(naphthalen-2-yl)-N,5-diphenyl-pyrazoline-1-carbothioamide derivatives were prepared. This report provides complete assignments of their (1) H and (13) C NMR data, which can be used to subsequently identify chalcones bearing pyrazoline-carbothioamide groups. Copyright © 2013 John Wiley & Sons, Ltd.

PMID: 23784987 [PubMed - as supplied by publisher]

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