[ASAP] NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain
NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain
Robert Creutznacher, Thorben Maass, Barbora Veselkova, George Ssebyatika, Thomas Krey, Martin Empting, Norbert Tautz, Martin Frank, Knut Ko?lbel, Charlotte Uetrecht, and Thomas Peters
https://pubs.acs.org/cms/10.1021/jacs.2c05603/asset/images/medium/ja2c05603_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.2c05603
nmrlearner
Journal club
0
07-16-2022 01:22 AM
[NMR paper] Solution NMR of Nanoparticles in Serum: Protein Competition Influences Binding Thermodynamics and Kinetics
Solution NMR of Nanoparticles in Serum: Protein Competition Influences Binding Thermodynamics and Kinetics
The spontaneous formation of a protein corona on a nanoparticle surface influences the physiological success or failure of the synthetic nanoparticle as a drug carrier or imaging agent used in vivo. A quantitative understanding of protein-nanoparticle interactions is therefore critical for the development of nanoparticle-based therapeutics. In this perspective, we briefly discuss the challenges and limitations of current approaches used for studying protein-nanoparticle binding in a...
nmrlearner
Journal club
0
09-06-2021 06:05 PM
[ASAP] Kinetics of Ligand–Protein Dissociation from All-Atom Simulations: Are We There Yet?
Kinetics of Ligand–Protein Dissociation from All-Atom Simulations: Are We There Yet?
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00977/20181227/images/medium/bi-2018-00977b_0001.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00977
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/g0rndKG96gY
More...
nmrlearner
Journal club
0
01-07-2019 05:49 AM
[NMR paper] Structural determinants of ligand binding in the ternary complex of human ileal bile acid-binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
Structural determinants of ligand binding in the ternary complex of human ileal bile acid-binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
Related Articles Structural determinants of ligand binding in the ternary complex of human ileal bile acid-binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
FEBS J. 2015 Nov 27;
Authors: Horváth G, Bencsura Á, Simon Á, Tochtrop GP, DeKoster GT, Covey DF, Cistola DP, Toke O
Abstract
Besides aiding digestion,...
nmrlearner
Journal club
0
11-29-2015 12:47 AM
TheProline Enamine Formation Pathway Revisited inDimethyl Sulfoxide: Rate Constants Determined via NMR
TheProline Enamine Formation Pathway Revisited inDimethyl Sulfoxide: Rate Constants Determined via NMR
Michael H. Haindl, Johnny Hioe and Ruth M. Gschwind
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.5b03420/20151006/images/medium/ja-2015-03420y_0008.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.5b03420
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/FFtVCyXk5zk
nmrlearner
Journal club
0
10-06-2015 10:39 PM
[NMR paper] Role of hydrophobic interactions in the encounter complex formation of plastocyanin and cytochrome f complex revealed by paramagnetic NMR spectroscopy.
Role of hydrophobic interactions in the encounter complex formation of plastocyanin and cytochrome f complex revealed by paramagnetic NMR spectroscopy.
Role of hydrophobic interactions in the encounter complex formation of plastocyanin and cytochrome f complex revealed by paramagnetic NMR spectroscopy.
J Am Chem Soc. 2013 Apr 29;
Authors: Scanu S, Förster J, Ullmann GM, Ubbink M
Abstract
Protein complex formation is thought to be at least a two-step process, in which the active complex is preceded by the formation of an encounter complex....
nmrlearner
Journal club
0
05-01-2013 11:46 AM
[NMR paper] 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand bi
15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition.
Related Articles 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition.
Biochemistry. 1994 Apr 12;33(14):4093-100
Authors: Cheng JW, Lepre CA, Moore JM
Backbone dynamics of the ligand- (FK506-) bound protein FKBP-12 (107 amino acids) have been examined using 15N relaxation data derived from inverse-detected two-dimensional...
nmrlearner
Journal club
0
08-22-2010 03:33 AM
[NMR paper] 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand bi
15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition.
Related Articles 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition.
Biochemistry. 1994 Apr 12;33(14):4093-100
Authors: Cheng JW, Lepre CA, Moore JM
Backbone dynamics of the ligand- (FK506-) bound protein FKBP-12 (107 amino acids) have been examined using 15N relaxation data derived from inverse-detected two-dimensional...
![[ASAP] Cosolvent Dimethyl Sulfoxide Influences Protein–Ligand Binding Kinetics via Solvent Viscosity Effects: Revealing the Success Rate of Complex Formation Following Diffusive Protein–Ligand Encounter](http://www.bionmr.com/forum/iconimages/journal-club-9/%5Basap%5D-cosolvent-dimethyl-sulfoxide-influences-protein%96ligand-binding-kinetics-via-solvent-viscosity-effects-revealing-success-rate-complex-formation-following-diffusive-protein%96ligand-encounter_ltr.gif)
[ASAP] Cosolvent Dimethyl Sulfoxide Influences Protein–Ligand Binding Kinetics via Solvent Viscosity Effects: Revealing the Success Rate of Complex Formation Following Diffusive Protein–Ligand Encounter
Linear Mode
