Postdoctoral Position "Solution Dynamics of Protein Kinases" in New York
Postdoctoral Position "Solution Dynamics of Protein Kinases" in New York
A postdoctoral position to study the solution dynamics and structure of protein kinases is available on a NIH funded project (REF#: HS-R-6453-10-08-S). Our group is interested in how static and dynamic changes of protein structure affect the activity of protein kinases. We combine X-ray crystallography, NMR and ligand binding kinetics with collaborative molecular dynamic studies (See e.g. ref 1 and 2). Our research group is located at Stony Brook University in a highly interactive environment with the New York Structural Biology Center and Brookhaven National Laboratory. Varian and Bruker NMR instruments with 500-700 MHz field strenghts are available on site. As a member of the New York Structural Biology Center, we have access to 800 MHz and 900 MHz instruments as well as a access to a large pool of NMR expertise. The location of Stony Brook University within public transport commuting distance to New York City and the north shore of Long Island provide a convenient work-life balance and a family friendly environment. Interested candidates with a strong background in protein NMR should email their CV and the names of three references to Markus Seeliger (markus.seeliger@gmail.com). 1.) Shan, Y., Seeliger, M.A., et al. A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proc Natl Acad Sci U S A, 2009. 106(1): p. 139-44. 2.) Seeliger, M.A., et al., Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res, 2009. 69(6): p. 2384-92. ************************************************** ***** Markus Seelige Assistant Professor Department of Pharmacological Sciences Stony Brook University Medical School, BST 7-125 Stony Brook, NY 11794-8651 phone: (631) 444-3558 fax: (631) 444-9749 http://www.pharm.stonybrook.edu/seeliger ************************************************** *****https://blogger.googleusercontent.co...s.blogspot.com More... |
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