BioNMR
NMR aggregator & online community since 2003
BioNMR    
Learn or help to learn NMR - get free NMR books!
 

Go Back   BioNMR > NMR career > Job marketplace
Advanced Search



Jobs Groups Conferences Literature Pulse sequences Software forums Programs Sample preps Web resources BioNMR issues


Webservers
NMR processing:
MDD
NMR assignment:
Backbone:
Autoassign
MARS
UNIO Match
PINE
Side-chains:
UNIO ATNOS-Ascan
NOEs:
UNIO ATNOS-Candid
UNIO Candid
ASDP
Structure from NMR restraints:
Ab initio:
GeNMR
Cyana
XPLOR-NIH
ASDP
UNIO ATNOS-Candid
UNIO Candid
Fragment-based:
BMRB CS-Rosetta
Rosetta-NMR (Robetta)
Template-based:
GeNMR
I-TASSER
Refinement:
Amber
Structure from chemical shifts:
Fragment-based:
WeNMR CS-Rosetta
BMRB CS-Rosetta
Homology-based:
CS23D
Simshift
Torsion angles from chemical shifts:
Preditor
TALOS
Promega- Proline
Secondary structure from chemical shifts:
CSI (via RCI server)
TALOS
MICS caps, β-turns
d2D
PECAN
Flexibility from chemical shifts:
RCI
Interactions from chemical shifts:
HADDOCK
Chemical shifts re-referencing:
Shiftcor
UNIO Shiftinspector
LACS
CheckShift
RefDB
NMR model quality:
NOEs, other restraints:
PROSESS
PSVS
RPF scores
iCing
Chemical shifts:
PROSESS
CheShift2
Vasco
iCing
RDCs:
DC
Anisofit
Pseudocontact shifts:
Anisofit
Protein geomtery:
Resolution-by-Proxy
PROSESS
What-If
iCing
PSVS
MolProbity
SAVES2 or SAVES4
Vadar
Prosa
ProQ
MetaMQAPII
PSQS
Eval123D
STAN
Ramachandran Plot
Rampage
ERRAT
Verify_3D
Harmony
Quality Control Check
NMR spectrum prediction:
FANDAS
MestReS
V-NMR
Flexibility from structure:
Backbone S2
Methyl S2
B-factor
Molecular dynamics:
Gromacs
Amber
Antechamber
Chemical shifts prediction:
From structure:
Shiftx2
Sparta+
Camshift
CH3shift- Methyl
ArShift- Aromatic
ShiftS
Proshift
PPM
CheShift-2- Cα
From sequence:
Shifty
Camcoil
Poulsen_rc_CS
Disordered proteins:
MAXOCC
Format conversion & validation:
CCPN
From NMR-STAR 3.1
Validate NMR-STAR 3.1
NMR sample preparation:
Protein disorder:
DisMeta
Protein solubility:
camLILA
ccSOL
Camfold
camGroEL
Zyggregator
Isotope labeling:
UPLABEL
Solid-state NMR:
sedNMR


Reply
Thread Tools Search this Thread Rate Thread Display Modes
  #1  
Unread 12-01-2010, 08:36 PM
nmrlearner's Avatar
Senior Member
 
Join Date: Jan 2005
Posts: 23,135
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 193,617
Downloads: 0
Uploads: 0
Default PhD Studentship

PhD Studentship

PhD Studentship Advertisement

Hosting organizations: Institute of Food Research, University of East Anglia, and John Innes Centre

Title: Allergen thermodynamics: The effect of structure and dynamics on the susceptibility of pollen and food allergens to proteolysis
Start date: October 2011
Deadline for applications: 6 December 2010
Project details:
The goal of the project is to define how protein structure and dynamics determine the susceptibility of birch pollen allergen and its homologues to low pH proteolysis. This knowledge will provide the rational basis for development of in silico methods for predicting digestibility of proteins, a cornerstone of genetically modified organism (GMO) allergenicity risk assessment.
We propose to compare the pH-induced unfolding pathways of birch pollen allergen superfamily members (Bet v 1, Mal d 1 and Api g 1), define its impact on patterns and pathways of proteolysis, and investigate the effects of mutations on this process. Unfolding will be characterised using CD, FT-IR and NMR spectroscopy as a function of pH. Unfolding experiments will be also performed in silico using Molecular Dynamics simulations on Cray supercomputer. In silico denatured states will
be compared against NMR results, thus describing the contribution of entropic and enthalpic processes to unfolding.
The student will receive a broad training in protein structure and characterisation, spanning protein biochemistry, heterologous expression and purification, proteolysis, proteomics, low resolution spectroscopy (fluorescence, CD and FT-IR) together within silico protein structure modelling and IgE-binding studies. This will be complemented by training in protein NMR spectroscopy, covering
multidimensional spectral acquisition, processing and assignment, structure calculation, and relaxation analysis. In addition to experimental studies the student will be trained to undertake molecular dynamics techniques for protein unfoldingin silico. Transferable skills training will include
presenting to and interacting with Professor Mills Food and Health Network Allergy cluster which includes industry and academic researchers with an interest in allergy.
Qualifications:
The candidate should be able to demonstrate an aptitude for structural biology. The particular areas include protein biochemistry, protein NMR, and structural biology.
Funding:
The studentship covers UK/EU tuition fees and an enhanced rate stipend in the region of £16,600 per annum as a result of funding restrictions it is available only to UK/EU students. Overseas student should NOT apply. Successful applicants will be interviewed as part of the studentship competition.
Enquiries:
Informal enquiries regarding the project should be directed to the project supervisors:
Clare Mills E-mail: clare.mills@bbsrc.ac.uk
Tharin Blumenschein E-mail: t.blumenschein@uea.ac.uk
Web-pages:
http://www.ifr.ac.uk/profile/clare-mills.as
http://www.uea.ac.uk/che/tb
How to apply:
For further information and an application form, please visit the 'How to Apply' page on our
website:
http://www.ifr.ac.uk/students/admissions.htm
Contact information:
Graduate Studies Office, John Innes Centre, Norwich Research Park,
Colney, Norwich, NR4 7UH, UK
Telephone: +44(0) 1603 450768
E-mail:graduates.nrp@bbsrc.ac.uk
-----------------------------------------
Dr. Tharin Blumenschein, Lecturer
t.blumenschein@uea.ac.uk
School of Chemistry
University of East Anglia
Norwich - NR4 7TJ
United Kingdom
Phone: +44 (0)1603 59 2963


More...
Reply With Quote


Did you find this post helpful? Yes | No

Reply
Similar Threads
Thread Thread Starter Forum Replies Last Post
PhD studentship
PhD studentship A 4 year PhD studentship contract is available in my group starting september 2012 to work on the structural and functional aspects of the recognition of chromatin structure by the ING4 tumor suppressor. We seek a motivated student with a strong interest in structural biology, and with a Master degree (to be completed before september 2012). The PhD researcher will be involved in sample preparation and structural analysis by NMR and other techniques. The laboratory hosts two Bruker spectrometers (800 and 600 MHz) with a full complement of probes for biomolecular...
nmrlearner Job marketplace 0 01-11-2012 04:10 PM
PhD studentship, Massey University, New Zealand
PhD studentship, Massey University, New Zealand PhD studentship, Massey University, New Zealand A PhD studentship is available to apply state-of-the-art NMR techniques, along with other biophysical approaches and computational analyses, to protein and RNA structure and dynamics. This project is a collaboration with the University of Sydney, where complementary Small Angle X-ray Scattering (SAXS) studies will be performed, and with the New York Structural Biology Center, which houses spectrometers up to 900 MHz. The Massey University Centre for Structural Biology houses a 700 MHz Bruker...
nmrlearner Job marketplace 0 09-01-2010 10:56 AM
PhD studentship in solid-state DNP/NMR - Lille, France
PhD studentship in solid-state DNP/NMR - Lille, France A three-years PhD position in solid-state DNP/NMR is available in the group of Prof. J.-P. Amoureux, University of Lille, Lille, France. It will start preferably in October 2010. The project: The Ph.D. project aims to develop a new technique for the characterization of materials : the Dynamic Nuclear Polarization (DNP) for solid-state samples at high magnetic field. Recently the group of R. G. Griffin at MIT demonstrated that this technique is feasible at high magnetic field (9.4 T) and increases the sensitivity of nuclear magnetic...
nmrlearner Job marketplace 0 08-21-2010 05:17 AM
PhD studentship in solid-state DNP/NMR - Lille, France
PhD studentship in solid-state DNP/NMR - Lille, France A three-years PhD position in solid-state DNP/NMR is available in the group of Prof. J.-P. Amoureux, University of Lille, Lille, France. It will start preferably in October 2010. The project: The Ph.D. project aims to develop a new technique for the characterization of materials : the Dynamic Nuclear Polarization (DNP) for solid-state samples at high magnetic field. Recently the group of R. G. Griffin at MIT demonstrated that this technique is feasible at high magnetic field (9.4 T) and increases the sensitivity of nuclear magnetic...
nmrlearner Job marketplace 0 08-21-2010 05:14 AM
Phd Studentship in NMR
PhD Studentship to Study Carbohydrate-Lectin Interactions by NMR Applications are invited for a PhD studentship at the Institute of Molecular Pharmacy in Basel, Switzerland. The central theme of the research will focus on the use of Nuclear Magnetic Resonance Spectroscopy to characterize Carbohydrate-Lectin interactions. The student would join the group of Prof. Beat Ernst and would be under the guidance of groups Habilitant, Dr. Brian Cutting. The student will benefit from daily interactions with others scientists
sivanmr Job marketplace 0 03-30-2006 07:54 PM


Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes Rate This Thread
Rate This Thread:

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On
Trackbacks are Off
Pingbacks are Off
Refbacks are Off



BioNMR advertisements to pay for website hosting and domain registration. Nobody does it for us.



Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Copyright, BioNMR.com, 2003-2013
Search Engine Friendly URLs by vBSEO 3.6.0

All times are GMT. The time now is 06:58 AM.


Map