An important clue as to the underlying mechanism of Alzheimer's disease has been identified using nuclear magnetic resonance (NMR) spectroscopy by researchers from the Lomonosov Moscow State University scientists and their colleagues from the Institute of Molecular Biology, Russian Academy of Sciences and the King's College London. They report details in the journal Scientific Reports.
Zinc deficiency:Hedgehog activation
Zinc deficiency:Hedgehog activation
http://www.spectroscopynow.com/common/images/thumbnails/14d04207a5f.jpgZinc deficiency, which is associated with various cancers, can lead to activation of the "Hedgehog" signalling pathway, according to evidence arising from studies that involved solution NMR spectroscopy.
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[NMR paper] 2D 1H and 3D 1H-15N NMR of zinc-rubredoxins: contributions of the beta-sheet to therm
2D 1H and 3D 1H-15N NMR of zinc-rubredoxins: contributions of the beta-sheet to thermostability.
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Protein Sci. 1996 May;5(5):883-94
Authors: Richie KA, Teng Q, Elkin CJ, Kurtz DM
...
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08-22-2010 02:27 PM
[NMR paper] Replacement of His23 by Cys in a zinc finger of HIV-1 NCp7 led to a change in 1H NMR-
Replacement of His23 by Cys in a zinc finger of HIV-1 NCp7 led to a change in 1H NMR-derived 3D structure and to a loss of biological activity.
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FEBS Lett. 1993 Sep 27;331(1-2):43-8
Authors: Julian N, Demene H, Morellet N, Maigret B, Roques BP
The nucleocapsid protein NCp7 of human...
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[NMR paper] Zinc- and sequence-dependent binding to nucleic acids by the N-terminal zinc finger o
Zinc- and sequence-dependent binding to nucleic acids by the N-terminal zinc finger of the HIV-1 nucleocapsid protein: NMR structure of the complex with the Psi-site analog, dACGCC.
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08-21-2010 11:53 PM
[NMR paper] 113Cd-NMR investigation of a cadmium-substituted copper, zinc-containing superoxide d
113Cd-NMR investigation of a cadmium-substituted copper, zinc-containing superoxide dismutase from yeast.
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Eur J Biochem. 1991 Jun 15;198(3):607-11
Authors: Kofod P, Bauer R, Danielsen E, Larsen E, Bjerrum MJ
113Cd nuclear magnetic resonance spectroscopy has been used to...
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08-21-2010 11:16 PM
[NMR paper] Structural characterization of a 39-residue synthetic peptide containing the two zinc
Structural characterization of a 39-residue synthetic peptide containing the two zinc binding domains from the HIV-1 p7 nucleocapsid protein by CD and NMR spectroscopy.
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FEBS Lett. 1991 Nov 4;292(1-2):25-30
Authors: Omichinski JG, Clore GM, Sakaguchi K, Appella E,...
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08-21-2010 11:12 PM
[NMR paper] Structural characterization of a 39-residue synthetic peptide containing the two zinc
Structural characterization of a 39-residue synthetic peptide containing the two zinc binding domains from the HIV-1 p7 nucleocapsid protein by CD and NMR spectroscopy.
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FEBS Lett. 1991 Nov 4;292(1-2):25-30
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[NMR paper] Alternating zinc fingers in the human male associated protein ZFY: refinement of the
Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition.
Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition.
Biochemistry. 1991 Jul 23;30(29):7063-72
Authors: Kochoyan M, Keutmann HT, Weiss MA
ZFY, a male-associated Zn-finger protein encoded by the human Y chromosome, exhibits a...
Zinc control: NMR untangles Alzheimer's
An important clue as to the underlying mechanism of Alzheimer's disease has been identified using nuclear magnetic resonance (NMR) spectroscopy by researchers from the Lomonosov Moscow State University scientists and their colleagues from the Institute of Molecular Biology, Russian Academy of Sciences and the King's College London. They report details in the journal Scientific Reports.
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