Bioactive peptidomimetic macrocycles have been developed by a group of scientists at Cornell University in Ithaca, New York, USA, and studied using nuclear magnetic resonance (NMR) spectroscopy.
Effective PHIP labeling of bioactive peptides boosts the intensity of the NMR signal
From The DNP-NMR Blog:
Effective PHIP labeling of bioactive peptides boosts the intensity of the NMR signal
Sauer, G., et al., Effective PHIP labeling of bioactive peptides boosts the intensity of the NMR signal. Angew Chem Int Ed Engl, 2014. 53(47): p. 12941-5.
http://www.ncbi.nlm.nih.gov/pubmed/25296746
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03-04-2015 08:57 PM
[NMR paper] Protein NMR Structures Refined with Rosetta Have Higher Accuracy Relative to Corresponding X-ray Crystal Structures.
Protein NMR Structures Refined with Rosetta Have Higher Accuracy Relative to Corresponding X-ray Crystal Structures.
Protein NMR Structures Refined with Rosetta Have Higher Accuracy Relative to Corresponding X-ray Crystal Structures.
J Am Chem Soc. 2014 Jan 6;
Authors: Mao B, Tejero R, Baker D, Montelione GT
Abstract
We have found that refinement of protein NMR structures using Rosetta with experimental NMR restraints yields more accurate protein NMR structures than those that have been deposited in the PDB using standard refinement...
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01-08-2014 11:23 AM
[NMR paper] Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation.
Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation.
Related Articles Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation.
Bioorg Med Chem. 2013 Jul 3;
Authors: Blundell CD, Packer MJ, Almond A
Abstract
Accurate unbound solution 3D-structures of ligands provide unique opportunities for medicinal chemistry and, in particular, a context to understand binding thermodynamics and kinetics. Previous methods of...
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07-28-2013 07:46 PM
[NMR paper] NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
Related Articles NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
Top Curr Chem. 2008;273:1-14
Authors: Blommers MJ, Strauss A, Geiser M, Ramage P, Sparrer H, Jahnke W
Abstract
Key processes in molecular biology are regulated by interactions between biomolecules. Protein-proteinand protein-ligand interactions, e.g., in signal transduction pathways, rely on the subtle interactionsbetween atoms at the binding interface of...
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04-24-2013 09:48 PM
87Sr Solid-StateNMR as a StructurallySensitive Tool for the Investigation of Materials: AntiosteoporoticPharmaceuticals and Bioactive Glasses
87Sr Solid-StateNMR as a StructurallySensitive Tool for the Investigation of Materials: AntiosteoporoticPharmaceuticals and Bioactive Glasses
Christian Bonhomme, Christel Gervais, Nicolas Folliet, Fre?de?rique Pourpoint, Cristina Coelho Diogo, Jonathan Lao, Edouard Jallot, Jose?phine Lacroix, Jean-Marie Nedelec, Dinu Iuga, John V. Hanna, Mark E. Smith, Ye Xiang, Jincheng Du and Danielle Laurencin
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja303505g/aop/images/medium/ja-2012-03505g_0001.gif
Journal of the American Chemical Society...
[NMR paper] Comparison of X-ray and NMR structures: is there a systematic difference in residue contacts between X-ray- and NMR-resolved protein structures?
Comparison of X-ray and NMR structures: is there a systematic difference in residue contacts between X-ray- and NMR-resolved protein structures?
Related Articles Comparison of X-ray and NMR structures: is there a systematic difference in residue contacts between X-ray- and NMR-resolved protein structures?
Proteins. 2005 Jul 1;60(1):139-47
Authors: Garbuzynskiy SO, Melnik BS, Lobanov MY, Finkelstein AV, Galzitskaya OV
We have compared structures of 78 proteins determined by both NMR and X-ray methods. It is shown that X-ray and NMR structures...
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12-01-2010 06:56 PM
[NMR paper] Metabonomics classifies pathways affected by bioactive compounds. Artificial neural n
Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts.
Related Articles Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts.
Phytochemistry. 2003 Mar;62(6):971-85
Authors: Ott KH, Araníbar N, Singh B, Stockton GW
The biochemical mode-of-action (MOA) for herbicides and other bioactive compounds can be rapidly and simultaneously classified by automated pattern recognition of...
Bioactive macrocycles: NMR structures
Bioactive peptidomimetic macrocycles have been developed by a group of scientists at Cornell University in Ithaca, New York, USA, and studied using nuclear magnetic resonance (NMR) spectroscopy.
Linear Mode
