A new approach to chiral synthesis that works under mild conditions has been validated with nuclear magnetic resonance (NMR) spectroscopy and other tools by scientists in Europe. Paolo Melchiorre of ICIQ, Institute Of Chemical Research Of Catalonia, and colleagues developed the technique using enantioselective iminium ion chemistry and photoredox catalysis to form quaternary carbon stereocentres with high enantioselectivity.
Nuclear overhauser spectroscopy of chiral CHD methylene groups
Nuclear overhauser spectroscopy of chiral CHD methylene groups
Abstract
Nuclear magnetic resonance spectroscopy (NMR) can provide a great deal of information about structure and dynamics of biomolecules. The quality of an NMR structure strongly depends on the number of experimental observables and on their accurate conversion into geometric restraints. When distance restraints are derived from nuclear Overhauser effect spectroscopy (NOESY), stereo-specific assignments of prochiral atoms can contribute significantly to the accuracy of NMR structures...
nmrlearner
Journal club
0
11-28-2015 10:23 AM
1H NMR Chiral Analysis of Charged Moleculesvia Ion Pairing with Aluminum Complexes
1H NMR Chiral Analysis of Charged Moleculesvia Ion Pairing with Aluminum Complexes
Min-Seob Seo and Hyunwoo Kim
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.5b09555/20151030/images/medium/ja-2015-095553_0006.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.5b09555
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/4hWxyFA9xrg
nmrlearner
Journal club
0
10-31-2015 07:16 PM
Chiral anomaly: An end to decades-long hunt
Chiral anomaly: An end to decades-long hunt
http://www.spectroscopynow.com/common/images/thumbnails/14fcb4a4eee.jpgThe 'chiral anomaly' was first posited in the 1960s and suggested to exist in crystalline materials in the 1980s but has only now been detected by conductivity measurements in a semi-metal compound of sodium and bismuth.
Read the rest at Spectroscopynow.com
nmrlearner
General
0
09-15-2015 11:12 AM
Mechanism of Enantioselective C-C Bond Formation with Bifunctional Chiral Ru Catalyst
Mechanism of Enantioselective C-C Bond Formation with Bifunctional Chiral Ru Catalysts: NMR and DFT Study
Ilya D. Gridnev, Masahito Watanabe, Hui Wang and Takao Ikariya
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja107597w/aop/images/medium/ja-2010-07597w_0026.gif
Journal of the American Chemical Society
DOI: 10.1021/ja107597w
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/r7kLNNUoGQg
nmrlearner
Journal club
0
10-28-2010 09:14 PM
[NMR paper] NMR Relaxation Mechanisms for Backbone Carbonyl Carbons in a 13 C, 15 N-Labeled Prote
NMR Relaxation Mechanisms for Backbone Carbonyl Carbons in a 13 C, 15 N-Labeled Protein
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR Relaxation Mechanisms for Backbone Carbonyl Carbons in a 13 C, 15 N-Labeled Protein
J Magn Reson. 1997 May;126(1):48-57
Authors: Allard P, Härd T
The predominant relaxation mechanisms for backbone carbonyl carbon (13 C') relaxation in a 13 C, 15 N-doubly enriched sample of the thermostable Sso7d protein have been investigated....
nmrlearner
Journal club
0
08-22-2010 03:31 PM
[NMR paper] NMR Relaxation Mechanisms for Backbone Carbonyl Carbons in a 13 C, 15 N-Labeled Prote
NMR Relaxation Mechanisms for Backbone Carbonyl Carbons in a 13 C, 15 N-Labeled Protein
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR Relaxation Mechanisms for Backbone Carbonyl Carbons in a 13 C, 15 N-Labeled Protein
J Magn Reson. 1997 May;126(1):48-57
Authors: Allard P, Härd T
The predominant relaxation mechanisms for backbone carbonyl carbon (13 C') relaxation in a 13 C, 15 N-doubly enriched sample of the thermostable Sso7d protein have been investigated....
All four corners: NMR and chiral carbons
A new approach to chiral synthesis that works under mild conditions has been validated with nuclear magnetic resonance (NMR) spectroscopy and other tools by scientists in Europe. Paolo Melchiorre of ICIQ, Institute Of Chemical Research Of Catalonia, and colleagues developed the technique using enantioselective iminium ion chemistry and photoredox catalysis to form quaternary carbon stereocentres with high enantioselectivity.
Linear Mode
