Thread: NMR paper In vitro NMR proton T1 measurements in peritoneal ascites.
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Default In vitro NMR proton T1 measurements in peritoneal ascites.
In vitro NMR proton T1 measurements in peritoneal ascites.

Related Articles In vitro NMR proton T1 measurements in peritoneal ascites.

Phys Med Biol. 1996 Mar;41(3):539-49

Authors: Yilmaz A, Tez M, Göral V, Boylu S, Kaplan A, Kavak G

The proton spin-lattice relaxation rate (1/T1) in malignant and non-malignant ascites was measured with an FT NMR spectrometer operating at 60 MHz. The mean relaxation rate in non-malignant ascites was significantly smaller than that of malignant ascites. However, the 1/T1 of malignant ascites overlaps with that of non-malignant ascites over all concentrations of total protein (TP) in samples. The 1/T1 in non-malignant ascites correlates strongly with TP, whilst the 1/T1 in malignant ascites shows only a moderate correlation. T1 measurements before and after addition of ascorbic acid (reductant) suggest that there is a small paramagnetic contribution of ions to the 1/T1 in malignant ascites. The least-squares fitting of 1/T1 versus TP for non-malignant data gives a linear relationship, and suggests that the T1 mechanism in non-malignant ascites is caused by a fast chemical exchange of water molecules between protein-bound water and free water.

PMID: 8778831 [PubMed - indexed for MEDLINE]



Source: PubMed
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