High-resolution NMR of biological solids.
Related Articles High-resolution NMR of biological solids.
Curr Opin Struct Biol. 1996 Oct;6(5):624-9
Authors: McDowell LM, Schaefer J
Solid-state NMR experiments have recently provided a number of biochemical insights: motionally averaged 2H lineshapes have shown that the motion of a backbone loop protecting a protein binding site is not ligand gated; isotropic 13C chemical shifts of freeze-quenched enzyme-ligand intermediates have revealed mechanistic details of reaction pathways; multiple heteronuclear distance determinations have characterized the binding-site geometry of a 46 kDa noncrystalline enzyme complex; and homonuclear recoupling experiments have established that insoluble amyloid fibrils form a pleated beta sheet.
PMID: 8913684 [PubMed - indexed for MEDLINE]
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PubMed