Thread: Single-scan 13C diffusion-ordered NMR spectroscopy of DNP-hyperpolarised substrates #DNPNMR
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Unread 09-13-2017, 08:48 PM
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Default Single-scan 13C diffusion-ordered NMR spectroscopy of DNP-hyperpolarised substrates #DNPNMR
From The DNP-NMR Blog:

Single-scan 13C diffusion-ordered NMR spectroscopy of DNP-hyperpolarised substrates #DNPNMR

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Guduff, L., et al., Single-scan 13C diffusion-ordered NMR spectroscopy of DNP-hyperpolarised substrates. Chemistry, 2017: p. n/a-n/a.


https://www.ncbi.nlm.nih.gov/pubmed/28857281


Diffusion-ordered NMR spectroscopy (DOSY) is a powerful approach for the analysis of molecular mixtures, yet its application range is limited by the relatively low sensitivity of NMR. We show here that spectrally resolved 13C DOSY data can be collected, in a single scan, for substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP), which provides signal enhancements of several orders of magnitude. For this we use a convection-compensation pulse scheme, which we also analyse by numerical simulation. The proposed method further allows the acquisition of several consecutive DOSY spectra in a single D-DNP experiment.
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