The spliceosome: NMR spFRET dice up protein complex
Prior to gene expression in the cell, the non-coding regions of the genome have to be removed by the spliceosome. A joint single pair Förster resonance energy transfer (spFRET) and nuclear magnetic resonance (NMR) spectroscopy study by researchers in Munich suggests that distinct conformations of a member of this molecular complex play a vital role in the process, with implications for biomedical science.
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