Targeting PP1: NMR takes aim
The enzyme PP1 plays a vital role in countless biochemical processes in the body and is the pivot around which many diseases turn. It is so ubiquitous that until now drug development has tended to avoid it because the side effects and complications that arise when it is targeted are too risky. Now, researchers at Brown University, have used NMR spectroscopy and X-ray crystallography to help them focus on how PP1 interacts with other proteins to understand specific behaviour that might nevertheless be...
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