DNP MAS NMR
A postdoc position for “DNP-enhanced solid-state NMR” will be available from September 2013 at the Helmholtz center Jülich/ Heinrich Heine-Universität Düsseldorf.One of the most demanding challenges of biomolecular NMR spectroscopy is the inherently low sensitivity. Signal enhancement by DNP is therefore a promising alternative to gain insights into systems which otherwise could not be investigated. We will exploit the technique to obtain structural information on complex systems (protein aggregates, and membrane proteins in lipid bilayers) which otherwise would be inaccessible to structural investigations. Further, the possibilities of this technique for selective enhancement will be exploited.The candidate should hold a PhD in Physics or Chemistry or a related field. Basic knowledge and experience in solid-state NMR or EPR spectroscopy as well as a strong interest in physics and structural biology is a prerequisite. Experience with DNP is highly desirable. The applicant should be highly motivated, open for new approaches and techniques, and able to tackle demanding challenges. As most of the systems involve collaborations with other research groups, good communication skills are required.The biomolecular NMR center of the Heinrich-Heine University of Düsseldorf at the Helmholtz Research Center Jülich (Forschungszentrum Jülich) offers an exciting and stimulating research environment. State-of-the art solid-state NMR spectrometers operating at 600 and 800 MHz are already available, a 600 MHz DNP spectrometer will be installed in September of 2013, and the installation of an 800 with DNP is scheduled for 2014.The position will be available for 2 years with the possibility of extension.
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