Thread: NMR techniques in drug delivery: Application to zein protein complexes
View Single Post
  #1  
Unread 02-03-2013, 10:13 AM
nmrlearner's Avatar
nmrlearner nmrlearner is offline
Senior Member
  
Join Date: Jan 2005
Posts: 23,178
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 0
Downloads: 0
Uploads: 0
Default NMR techniques in drug delivery: Application to zein protein complexes
NMR techniques in drug delivery: Application to zein protein complexes

15 December 2012
Publication year: 2012
Source:International Journal of Pharmaceutics, Volume 439, Issues 1–2



Zein is a protein containing a large amount of nonpolar amino acids, which has shown the ability to form aggregates and entrap solutes, such as drugs and amino acids. NMR techniques were used to detect binding interactions and measure affinity between zein and three different drugs: tetracycline, amoxicillin and indomethacin. The release study of zein microparticle formulations containing any of these drugs was confronted with the affinity results, showing a remarkable correlation. The feasible methodology employed, focused in the functionality of the protein–drug interaction, can be very promising for the rational design of appropriate drug vehicles for drug delivery.
Graphical abstract







More...
Reply With Quote

Did you find this post helpful? Yes | No